Discerning the genetics and epigenetics of chronic rhinosinusitis (CRS) may optimize
outcomes through early diagnostics, personalized and novel therapeutics, and early
prognostication. CRS associated with cystic fibrosis and primary ciliary dyskinesia has well-
characterized genetic mutations. Most CRS subjects, however, do not exhibit identifiable
monogenic alterations. Clustering in related individuals is seen in CRS with nasal polyps.
Spouses of subjects with CRS without nasal polyps also may be at increased risk of the …