Genome-wide association studies: a primer

A Corvin, N Craddock, PF Sullivan - Psychological medicine, 2010 - cambridge.org
There have been nearly 400 genome-wide association studies (GWAS) published since
2005. The GWAS approach has been exceptionally successful in identifying common genetic …

Genome-wide association studies in mice

J Flint, E Eskin - Nature Reviews Genetics, 2012 - nature.com
… of human genome-wide association studies (GWASs), which have discovered hundreds of
genes that are involved in dozens of common diseases 2 . However, the mouse studies also …

[HTML][HTML] Guidelines for genome-wide association studies

GS Barsh, GP Copenhaver, G Gibson… - PLoS genetics, 2012 - journals.plos.org
… Overall, when genome-wide information is used to analyze these studies, we will require
genome-wide significance thresholds analogous to those used in human studies in order to …

Genome-wide association studies of cancer

ZK Stadler, P Thom, ME Robson, JN Weitzel… - Journal of Clinical …, 2010 - ascopubs.org
… advances in genotyping technology have made possible genome-wide association studies
(GWAS) of human diseases. These studies have identified many important regions of genetic …

[HTML][HTML] The pursuit of genome-wide association studies: where are we now?

CS Ku, EY Loy, Y Pawitan, KS Chia - Journal of human genetics, 2010 - nature.com
… It is now 5 years since the first genome-wide association studies (GWAS), published in 2005…
optimistic about the prospect of the genome-wide association approach. However, most of …

Biostatistical aspects of genomewide association studies

A Ziegler, IR König… - … Journal: Journal of …, 2008 - Wiley Online Library
… human genome for association is a novel and promising approach to unravelling the
genetic basis of complex genetic diseases. In these genome-wide association studies (GWAs), …

Genome-wide association studies of cancer: current insights and future perspectives

A Sud, B Kinnersley, RS Houlston - Nature Reviews Cancer, 2017 - nature.com
… This Review focuses on the major findings from association studies, in particular, genome-wide
association studies (GWAS), in terms of understanding both the allelic architecture of …

Genome-wide association studies in cancer

DF Easton, RA Eeles - Human molecular genetics, 2008 - academic.oup.com
Genome-wide association studies (GWAS) provide a powerful approach to identify common,
low-penetrance disease loci without prior knowledge of location or function. GWAS have …

Genome-wide association studies: progress and potential for drug discovery and development

SF Kingsmore, IE Lindquist, J Mudge… - Nature Reviews Drug …, 2008 - nature.com
Genome-wide association (GWA) studies represent a new approach to identify common …
However, during the past year, a novel genetic approach — genome-wide association (GWA) — …

Current status of genome-wide association studies in cancer

CC Chung, SJ Chanock - Human genetics, 2011 - Springer
… alleles, particularly those discovered in genome-wide screens, contribute through alterations
in … Genome-wide association studies (GWAS) have emerged as an important tool for …