We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1
(3,941 cases and 7,848 controls), we replicated the established association with the
apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P= 1.8× 10− 157) and
observed genome-wide significant association with SNPs at two loci not previously
associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P= 1.4× …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we
conducted a large genome-wide association study of 2,032 individuals from France with
Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive
evidence of association (P< 10− 5) were examined in collections from Belgium, Finland, Italy
and Spain totaling 3,978 Alzheimer's disease cases and 3,297 controls. Two loci gave …