Peroxisome proliferator-activated receptor (PPAR) agonists are currently used
therapeutically in humans, even though many of their direct gene targets are unknown.
Because PPARs can directly regulate gene expression through peroxisome proliferator
response elements (PPREs), we pursued the computational prediction of PPREs on a
genome-wide scale. Contrary to current hypotheses, PPREs are not isotype-specific, nor do
flanking nucleotides confer additional information. However, a position weight matrix-based …