Genomic analysis of 1, 25-dihydroxyvitamin D3 action in mouse intestine reveals compartment and segment-specific gene regulatory effects
R Aita, D Aldea, S Hassan, J Hur… - Journal of Biological …, 2022 - ASBMB
1, 25-dihydroxyvitamin D (VD) regulates intestinal calcium absorption in the small intestine
(SI) and also reduces risk of colonic inflammation and cancer. However, the intestine
compartment-specific target genes of VD signaling are unknown. Here, we examined VD
action across three functional compartments of the intestine using RNA-seq to measure VD-
induced changes in gene expression and Chromatin Immunoprecipitation with next
generation sequencing to measure vitamin D receptor (VDR) genomic binding. We found …
(SI) and also reduces risk of colonic inflammation and cancer. However, the intestine
compartment-specific target genes of VD signaling are unknown. Here, we examined VD
action across three functional compartments of the intestine using RNA-seq to measure VD-
induced changes in gene expression and Chromatin Immunoprecipitation with next
generation sequencing to measure vitamin D receptor (VDR) genomic binding. We found …
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