[HTML][HTML] Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer
A Krohn, T Diedler, L Burkhardt, PS Mayer… - The American journal of …, 2012 - Elsevier
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is often
altered in prostate cancer. To determine the prevalence and clinical significance of the
different mechanisms of PTEN inactivation, we analyzed PTEN deletions in TMAs containing
4699 hormone-naïve and 57 hormone-refractory prostate cancers using fluorescence in situ
hybridization analysis. PTEN mutations and methylation were analyzed in subsets of 149
and 34 tumors, respectively. PTEN deletions were present in 20.2%(458/2266) of prostate …
altered in prostate cancer. To determine the prevalence and clinical significance of the
different mechanisms of PTEN inactivation, we analyzed PTEN deletions in TMAs containing
4699 hormone-naïve and 57 hormone-refractory prostate cancers using fluorescence in situ
hybridization analysis. PTEN mutations and methylation were analyzed in subsets of 149
and 34 tumors, respectively. PTEN deletions were present in 20.2%(458/2266) of prostate …
323 GENOMIC DELETION OF PTEN IS ASSOCIATED WITH TUMOR PROGRESSION AND EARLY PSA RECURRENCE IN ERG FUSION POSITIVE AND FUSION …
T Schlomm, L Burkhardt, P Stahl… - The Journal of …, 2012 - auajournals.org
METHODS To determine the prevalence and clinical significance of different mechanisms of
PTEN inactivation, we analyzed 4,699 hormone-naïve and 57 hormone-refractory prostate
cancers by fluorescence in situ hybridization for PTEN deletion. In addition, PTEN mutations
and promoter methylation were analyzed in subsets of 149 and 34 tumors. RESULTS PTEN
deletions were present in 20.2%(458/2,266) of prostate cancers harboring and
heterozygous (8.1%) and homozygous (12.1%) deletions. Deletions of PTEN were linked to …
PTEN inactivation, we analyzed 4,699 hormone-naïve and 57 hormone-refractory prostate
cancers by fluorescence in situ hybridization for PTEN deletion. In addition, PTEN mutations
and promoter methylation were analyzed in subsets of 149 and 34 tumors. RESULTS PTEN
deletions were present in 20.2%(458/2,266) of prostate cancers harboring and
heterozygous (8.1%) and homozygous (12.1%) deletions. Deletions of PTEN were linked to …
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