… early-onset leukodystrophy genes and genes expressed in fetal brain endothelial cells,
suggesting early-life mechanisms. … biology of PVS and cerebral small vessel disease, pointing to …

… Second, we explored genome-wide genetic correlations of PVS burden with MRI-markers
of brain aging, putative risk factors, and neurological diseases using LD-score regression.We …

… vascular cognitive, and infectious disorders. Conclusion: In this first gene-mapping study of
PVS, one of the earliest MRI-markers of cSVD, we describe 24 genome-wide significant risk …

… mechanisms and on cSVD and dementia pathophysiology. We sought to examine the genetic
contribution to dPVS burden … , derived from genome-wide genotypes, for dPVS burden, in …

… the neurovascular unit and blood-brain barrier with increased inflammation and permeability…
include the perivascular spaces that become dilated to form enlarged perivascular spaces (…

… , enlarged perivascular spaces, and cerebral microbleeds. … on recent advances in the
genetics of CSVD. The knowledge … is not their presence but the burden of PVS that seems to be …

… The first GWAS of WMH burden was performed leveraging the … have followed this first attempt
to unravel SVS genetics. … , as well as dilated perivascular spaces and lacunar infarction [28, …

… between extensive basal ganglia perivascular space burden and IS from various … Genomics
of perivascular space burden unravels early mechanisms of cerebral small vessel disease…

… cerebral small vessel disease, resulting in a triad of movement disorders, massively dilated
perivascular spaces on brain MRI, … (Arg243Trp) variant had a slightly increased dPVS burden …

… to identify determinants of PVS burden in a pooled analysis … assessed in this study, such as
genetics, could well play a role. … to unravel whether mechanisms truly differ across ethnicities. …