[HTML][HTML] Genotoxic effect of Bothrops snake venoms and isolated toxins on human lymphocyte DNA

S Marcussi, RG Stábeli, NA Santos-Filho, DL Menaldo… - Toxicon, 2013 - Elsevier
In the present study, micronucleus with cytokinesis blocking and comet assays were used to
evaluate the genotoxic potential of Bothrops jararacussu, Bothrops atrox, Bothrops moojeni,
Bothrops alternatus (Rhinocerophis alternatus) and Bothrops brazili snake venoms, and
also of some isolated toxins (MjTX-I, BthTX-I and II myotoxins, BjussuMP-II metalloprotease,
and BatxLAAO l-amino acid oxidase) on human lymphocytes. Significant DNA damages
were observed, indicating genotoxic potential after exposure of the lymphocytes to the toxins …
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