Gibepyrones: α-pyrones from Gibberella fujikuroi
AF Barrero, JE Oltra, MM Herrador, E Cabrera… - Tetrahedron, 1993 - Elsevier
… fujikuroi accounts for the biosynthesis of 2, which after subsequent oxidation pathways
would produce 4. Gibepyrone E is derived from the epoxidation of the exocyclic double bond
of 1, and gibepyrone F resulting from oxidative cleavage of the same bond The coexistence
of 2 and 4 in the culture medium pointed to the possibility of a biogenetic intermed& with
an aldehyde function at C-3’. Not being able to isolate this product in any broth culture we
tried to determine its occurrence by means of HPLC analysis of the media. Accordingly …
would produce 4. Gibepyrone E is derived from the epoxidation of the exocyclic double bond
of 1, and gibepyrone F resulting from oxidative cleavage of the same bond The coexistence
of 2 and 4 in the culture medium pointed to the possibility of a biogenetic intermed& with
an aldehyde function at C-3’. Not being able to isolate this product in any broth culture we
tried to determine its occurrence by means of HPLC analysis of the media. Accordingly …