Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow
Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-
characterized. We show here that 'hybrid'neutrophils with dendritic features–including
morphological complexity, expression of antigen presentation genes, and the ability to
process exogenous peptide and stimulate MHCII-dependent T cell activation–accumulate
intratumorally and suppress tumor growth in vivo. Trajectory analysis of patient TAN scRNA-
seq identifies this phenotype as a polarization state which is distinct from canonical cytotoxic …
characterized. We show here that 'hybrid'neutrophils with dendritic features–including
morphological complexity, expression of antigen presentation genes, and the ability to
process exogenous peptide and stimulate MHCII-dependent T cell activation–accumulate
intratumorally and suppress tumor growth in vivo. Trajectory analysis of patient TAN scRNA-
seq identifies this phenotype as a polarization state which is distinct from canonical cytotoxic …
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