Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets
S Toropainen, EA Niskanen, M Malinen, P Sutinen… - Scientific reports, 2016 - nature.com
Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a
critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that
typically express amplified levels of the AR. CRPC-derived VCaP cells display an excessive
number of chromatin AR-binding sites (ARBs) most of which localize to distal inter-or
intragenic regions. Here, we analyzed direct transcription programs of the AR in VCaP cells
using global nuclear run-on sequencing (GRO-seq) and integrated the GRO-seq data with …
critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that
typically express amplified levels of the AR. CRPC-derived VCaP cells display an excessive
number of chromatin AR-binding sites (ARBs) most of which localize to distal inter-or
intragenic regions. Here, we analyzed direct transcription programs of the AR in VCaP cells
using global nuclear run-on sequencing (GRO-seq) and integrated the GRO-seq data with …
Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets
T Sari, M Marjo, S Päivi - 2016 - erepo.uef.fi
Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a
critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that
typically express amplified levels of the AR. CRPC-derived VCaP cells display an excessive
number of chromatin AR-binding sites (ARBs) most of which localize to distal inter-or
intragenic regions. Here, we analyzed direct transcription programs of the AR in VCaP cells
using global nuclear run-on sequencing (GRO-seq) and integrated the GRO-seq data with …
critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that
typically express amplified levels of the AR. CRPC-derived VCaP cells display an excessive
number of chromatin AR-binding sites (ARBs) most of which localize to distal inter-or
intragenic regions. Here, we analyzed direct transcription programs of the AR in VCaP cells
using global nuclear run-on sequencing (GRO-seq) and integrated the GRO-seq data with …
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