Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

…, V Vitart, T Spector, YS Aulchenko, G Lauc… - Science …, 2020 - science.org
genes with a plausible role in IgG glycosylation, we assessed whether variants were located
in the coding regions of genes, showed pleiotropy with gene … enrichment in gene sets from …

Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function

…, T Esko, C Hayward, JF Wilson, G Lauc… - … Molecular Genetics, 2021 - academic.oup.com
… involved in regulation of glycosylation biochemical pathways. … N-glycosylation and to
investigate possible pleiotropic effects … network and proposed new regulators of IgG glycosylation. …

Genetic regulation of immunoglobulin G glycosylation

A Frkatovic, OO Zaytseva, L Klaric - Antibody Glycosylation, 2021 - Springer
… that have a big effect on glycosylation, many other genes with … Pleiotropy between glycosylation
and gene expression was … the network analysis for non-glycosylation genes influencing …

Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

G Lauc, JE Huffman, M Pučić, L Zgaga… - … genetics, 2013 - journals.plos.org
… To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans
… 16 genetic loci that are likely to be part of a much larger genetic network that regulates the …

Heritability enrichment of immunoglobulin G N-glycosylation in specific tissues

X Li, H Wang, Y Zhu, W Cao, M Song, Y Wang… - Frontiers in …, 2021 - frontiersin.org
regulated genes associated with IgG N-glycosylation traits … (PPI) network for the connectivity
of the genes by GeneNetwork v2.… The pleiotropic gene findings in this study can confirm that …

Genome-wide association study on immunoglobulin G glycosylation patterns

…, E Benedetti, R Plomp, G Razdorov… - Frontiers in …, 2018 - frontiersin.org
… A complex dynamic network, including genetic and epigenetic factors, regulates the … far is
immunoglobulin G (IgG) (17). Its glycosylation is thought to have important regulatory functions …

[HTML][HTML] Twelve years of genome-wide association studies of human protein N-glycosylation

A Timoshchuk, S Sharapov, YS Aulchenko - Engineering, 2023 - Elsevier
… of the genetic regulation of the populational variation of … and the N-glycosylation of
immunoglobulin G and transferrin. While … genetic region may be due to pleiotropic effects of the …

Influence of genetic and environmental factors on N-glycosylation of immunoglobulin G and total plasma proteins determined by twin study

T Keser - 2016 - repozitorij.unizg.hr
… a general regulatory effect influencing the glycosylation of … large variability of plasma
proteins and immunoglobulin G (… N-glycosylation of human immunoglobulin G show pleiotropy

The genetics and epidemiology of N- and O-immunoglobulin A glycomics

A Visconti, N Rossi, A Bondt, AH Ederveen, G Thareja… - Genome medicine, 2024 - Springer
… b Correlation network of IgA and IgG N-linked glycosylation derived traits. Each node … -glycosylation,
suggesting shared genetic and environmental mechanisms of immune regulation to …

Genome-wide association study of the human immunoglobulin G N-glycome

A Frkatović - 2022 - repozitorij.pmf.unizg.hr
… The identified loci were also shown to be pleiotropic with … the genes involved in the process
of IgG N-glycosylation by … The complex regulatory network behind protein glycosylation