Green approach: an efficient synthesis of 2, 4-disubstituted-1, 3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation
Research on Chemical Intermediates, 2015•Springer
An efficient and rapid procedure for the synthesis of 2, 4-disubstituted-1, 3-thiazoles and
selenazoles has been described by the reaction of α-bromoketones with thiourea,
phenylthiourea and selenourea at ambient temperature in aqueous medium under
ultrasonic irradiation. Analytically pure products were formed within 10–60 s in excellent
yields. The advantageous features of this non-conventional methodology over conventional
methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild …
selenazoles has been described by the reaction of α-bromoketones with thiourea,
phenylthiourea and selenourea at ambient temperature in aqueous medium under
ultrasonic irradiation. Analytically pure products were formed within 10–60 s in excellent
yields. The advantageous features of this non-conventional methodology over conventional
methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild …
Abstract
An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10–60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.
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