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[HTML][HTML] Group A β-hemolytic streptococcal infection in children and the resultant neuro-psychiatric disorder; a cross sectional study; Tehran, Iran

FE Taj, S Noorbakhsh, SG Darestani… - Basic and Clinical …, 2015 - ncbi.nlm.nih.gov
FE Taj, S Noorbakhsh, SG Darestani, E Shirazi, S Javadinia
Basic and Clinical Neuroscience, 2015•ncbi.nlm.nih.gov
Methods: Across sectional study was done in 2 pediatric psychiatric/and neurologic clinics in
Tehran (Rasul Akram and Aliasghar Hospital) during 2008–2010. We studied serum anti-
streptococcal antibodies (anti streptolysin O, anti Deoxyribonuclease B, and anti-
streptokinase (ABcam-ELISA, USA) in 76 cases with psychiatric manifestation (OCD, ADHD)
in compare with 39 healthy controls. These antibodies were studied in 53 cases with
movement disorders (Tic/Tourette syndrome) in compare with 76 healthy controls …
Methods:
Across sectional study was done in 2 pediatric psychiatric/and neurologic clinics in Tehran (Rasul Akram and Aliasghar Hospital) during 2008–2010. We studied serum anti-streptococcal antibodies (anti streptolysin O, anti Deoxyribonuclease B, and anti-streptokinase (ABcam-ELISA, USA) in 76 cases with psychiatric manifestation (OCD, ADHD) in compare with 39 healthy controls. These antibodies were studied in 53 cases with movement disorders (Tic/Tourette syndrome) in compare with 76 healthy controls. Sensitivity, specificity and positive predictive value of tests were calculated.
Results:
In movement disorders ASOT, Anti-DNase and Anti streptokinase was significantly higher than controls (P< 0.0001, P= 0.000, P< 0.00001)
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