A prominent feature of late-onset neurodegenerative diseases is accumulation of misfolded
protein in vulnerable neurons. When levels of misfolded protein overwhelm degradative
pathways, the result is cellular toxicity and neurodegeneration. Cellular mechanisms for
degrading misfolded protein include the ubiquitin-proteasome system (UPS), the main non-
lysosomal degradative pathway for ubiquitinated proteins, and autophagy, a lysosome-
mediated degradative pathway. The UPS and autophagy have long been viewed as …

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and
the UPS | CiNii Research … HDAC6 rescues neurodegeneration and provides an essential
link between autophagy and the UPS …