Heat shock drives genomic instability and phenotypic variations in yeast
High temperature causes ubiquitous environmental stress to microorganisms, but studies
have not fully explained whether and to what extent heat shock would affect genome
stability. Hence, this study explored heat-shock-induced genomic alterations in the yeast
Saccharomyces cerevisiae. Using genetic screening systems and customized single
nucleotide polymorphism (SNP) microarrays, we found that heat shock (52° C) for several
minutes could heighten mitotic recombination by at least one order of magnitude. More than …
have not fully explained whether and to what extent heat shock would affect genome
stability. Hence, this study explored heat-shock-induced genomic alterations in the yeast
Saccharomyces cerevisiae. Using genetic screening systems and customized single
nucleotide polymorphism (SNP) microarrays, we found that heat shock (52° C) for several
minutes could heighten mitotic recombination by at least one order of magnitude. More than …
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