Hepcidin-orchestrated hemogram and iron homeostatic patterns in two models of subchronic hepatic injury
I Gheith, ELM Abubakr - Biomedical and Environmental Sciences, 2019 - Elsevier
Objective This study was designed to evaluate hematological disorders and the
orchestrating roles of hepcidin and IL-6 in rat models of thioacetamide (TAA) and carbon
tetrachloride (CCl 4) hepatotoxicity. Methods Rats were intraperitoneally injected with TAA
(10 mg/100 g rat weight dissolved in isosaline) or CCl 4 (100 μL/100 g rat weight diluted as
1: 4 in corn oil) twice weekly for eight consecutive weeks to induce subchronic liver fibrosis.
Blood and tissue samples were collected and analyzed. Results CCl 4 but not TAA …
orchestrating roles of hepcidin and IL-6 in rat models of thioacetamide (TAA) and carbon
tetrachloride (CCl 4) hepatotoxicity. Methods Rats were intraperitoneally injected with TAA
(10 mg/100 g rat weight dissolved in isosaline) or CCl 4 (100 μL/100 g rat weight diluted as
1: 4 in corn oil) twice weekly for eight consecutive weeks to induce subchronic liver fibrosis.
Blood and tissue samples were collected and analyzed. Results CCl 4 but not TAA …
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