Herbimycin A induces the 20 S proteasome-and ubiquitin-dependent degradation of receptor tyrosine kinases
L Sepp-Lorenzino, Z Ma, DE Lebwohl, A Vinitsky… - Journal of Biological …, 1995 - ASBMB
Herbimycin A is an ansamycin antibiotic isolated as an agent that reverses morphological
transformation induced by v-src. Although herbimycin A is widely used as a tool for inhibiting
multiple tyrosine protein kinases and tyrosine kinase-activated signal transduction, its
mechanism of action is not well defined and includes a decrease in both tyrosine kinase
protein levels and activity (Uehara, Y., Murakami, Y., Sugimoto, Y., and Mizuno, S.(1989)
Cancer Res. 49, 780-785). We now show that herbimycin A induces a profound decrease in …
transformation induced by v-src. Although herbimycin A is widely used as a tool for inhibiting
multiple tyrosine protein kinases and tyrosine kinase-activated signal transduction, its
mechanism of action is not well defined and includes a decrease in both tyrosine kinase
protein levels and activity (Uehara, Y., Murakami, Y., Sugimoto, Y., and Mizuno, S.(1989)
Cancer Res. 49, 780-785). We now show that herbimycin A induces a profound decrease in …