Hesperidin occurs in greatest concentration in plants from the Rutaceae and Lamiaceae
families. In human nutrition it contributes to the integrity of blood vessels and its deficiency in
the diet has been linked to abnormal capillary leakiness as well as pain. In this study, the
bioflavonoid hesperidin was identified as an active compound in an ethanol extract of the
Rosmarinus officinalis aerial parts tested in the pain-induced functional impairment model in
the rat (PIFIR) as an assay of inflammatory and chronic nociception similar to that observed …