Heterogeneity of treatment effects of hydrocortisone by risk of bronchopulmonary dysplasia or death among extremely preterm infants in the national institute of child …

SJ Gentle, MA Rysavy, L Li, MM Laughon… - JAMA Network …, 2023 - jamanetwork.com
Importance Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are
at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National
Institute of Child Health and Human Development Neonatal Research Network (NICHD
NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates of BPD or death nor
increased rates of neurodevelopmental impairment (NDI) or death. Objective To determine
whether estimated risk for grades 2 to 3 BPD or death is associated with the effect of …
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