… and all lower-order—single, 2-, 3-, and 4-drug—combinations. We found that a majority of
all combinations—54%—contain hidden suppression. Examining hidden interactions is critical …

… in determining the interaction type of higher order drug combinations. … that higher-order
drug combinations exhibit a large number of suppressive interactions, and these interactions are …

… Most cases of suppression we find (97%) are “hidden” cases for which the triple-… We find
a surprising number of suppressive interactions in higher-order drug combinations. Without …

… higher order emergent interactions are much more common … that for many combinations the
higher order effects are not … highly synergistic and suppressive emergent interactions that we …

… diseases are often the result of intricate interactions among … suppressive activity when used
alone, but their combination … operator to infer higher-order correlation among data[22]. The …

… our approach for quantifying and understanding higher-order interactions. In doing so, we
create a framework to classify higher-order combinations of stressors by examining net three-…

… Additionally, we found that hidden suppressive interactions—where a pairwise interaction is
… Here we show that emergent hidden suppressive interactions are common and identifying …

… of combinations also exhibit hidden suppression… hidden suppressive interactions are
common: the majority (65%) of our re-analyzed stressor combinations revealed hidden suppression …

… S7) to those from maximum entropy calculations guarantees that they contain no hidden …
still numerous ways that pairwise interactions can be combined to yield higher-order drug …

… of drug interaction, hidden suppression, in 3-, 4-, and 5- drug … a hidden suppressive interaction,
a net additive combination … Hidden suppressive interactions are common in higherorder …