Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of
Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity,
microglial activation, and neuroinflammation. Signaling deficiencies in the hypothalamic
peptide orexin and/or orexin fiber loss are linked to neurodegeneration, cognitive
impairment, and neuroinflammation. Prior studies show that orexin is neuroprotective,
suppresses neuroinflammation, and that treatment with orexin improves cognitive processes …

Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of
Alzheimer's disease (AD). Diets high in saturated fat can potentiate the onset of obesity,
microglial activation, and neuroinflammation. Signaling deficiencies in the hypothalamic
peptide orexin A (OXA) and/or orexin fiber loss are linked to neurodegeneration in humans
and animal models. Prior studies in orexin/ataxin‐3 (O/A3) mice, a transgenic mouse model
of orexin neurodegeneration, demonstrate that OXA treatment improves cognitive …