High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution
S Chakrabarti, S Mackinnon, R Chopra… - Blood, The Journal …, 2002 - ashpublications.org
Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of
diseases, but little is known about its impact on the incidence of infections and immune
reconstitution. We examined the pattern and outcome of cytomegalovirus (CMV) infections
monitored by polymerase chain reaction–based assays and treated preemptively in 101
patients following nonmyeloablative conditioning containing in vivo Campath-1H. Fifty-one
patients (50%) had a CMV infection at a median of 27 days after transplantation with a …
diseases, but little is known about its impact on the incidence of infections and immune
reconstitution. We examined the pattern and outcome of cytomegalovirus (CMV) infections
monitored by polymerase chain reaction–based assays and treated preemptively in 101
patients following nonmyeloablative conditioning containing in vivo Campath-1H. Fifty-one
patients (50%) had a CMV infection at a median of 27 days after transplantation with a …
High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.
SC Suparno Chakrabarti, S Mackinnon… - 2002 - cabidigitallibrary.org
Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of
diseases, but little is known about its impact on the incidence of infections and immune
reconstitution. Between June 1997 and February 2001, a total of 101 patients from the UK
were enrolled in this study. The pattern of cytomegalovirus (CMV) reactivation and outcome
using polymerase chain reaction-guided preemptive therapy were examined in these
patients undergoing nonmyeloablative conditioning. Conditioning treatment consisted of …
diseases, but little is known about its impact on the incidence of infections and immune
reconstitution. Between June 1997 and February 2001, a total of 101 patients from the UK
were enrolled in this study. The pattern of cytomegalovirus (CMV) reactivation and outcome
using polymerase chain reaction-guided preemptive therapy were examined in these
patients undergoing nonmyeloablative conditioning. Conditioning treatment consisted of …
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