High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction
MR Bauza, CS Giménez, P Locatelli… - Drug Delivery and …, 2019 - Springer
In rodents with acute myocardial infarction (AMI), high mobility group box 1 (HMGB1)
injection has produced controversial results. Given the lack of data in large mammals, we
searched the dose that would promote angiogenesis and expression of specific
regenerative genes in sheep with AMI (protocol 1) and, subsequently, use this dose to study
long-term effects on infarct size and left ventricular (LV) function (protocol 2). Protocol 1:
Sheep with AMI received 250 μg (high-dose, n= 7), 25 μg (low-dose, n= 7) HMGB1, or PBS …
injection has produced controversial results. Given the lack of data in large mammals, we
searched the dose that would promote angiogenesis and expression of specific
regenerative genes in sheep with AMI (protocol 1) and, subsequently, use this dose to study
long-term effects on infarct size and left ventricular (LV) function (protocol 2). Protocol 1:
Sheep with AMI received 250 μg (high-dose, n= 7), 25 μg (low-dose, n= 7) HMGB1, or PBS …
[PDF][PDF] High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction
M del Rosario Bauzá, CS Giménez… - Drug Delivery and …, 2019 - academia.edu
In rodents with acute myocardial infarction (AMI), high mobility group box 1 (HMGB1)
injection has produced controversial results. Given the lack of data in large mammals, we
searched the dose that would promote angiogenesis and expression of specific
regenerative genes in sheep with AMI (protocol 1) and, subsequently, use this dose to study
long-term effects on infarct size and left ventricular (LV) function (protocol 2). Protocol 1:
Sheep with AMI received 250 μg (high-dose, n= 7), 25 μg (lowdose, n= 7) HMGB1, or PBS …
injection has produced controversial results. Given the lack of data in large mammals, we
searched the dose that would promote angiogenesis and expression of specific
regenerative genes in sheep with AMI (protocol 1) and, subsequently, use this dose to study
long-term effects on infarct size and left ventricular (LV) function (protocol 2). Protocol 1:
Sheep with AMI received 250 μg (high-dose, n= 7), 25 μg (lowdose, n= 7) HMGB1, or PBS …
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