… systematic dissection of noncoding loci can identify functional elements involved in gene
regulation and cancer drug resistance. In combination with other genome-wide assays, we …

… genome, it lacks mRNA and protein production as functional … and identify functional
elements within the non-coding genome … /GOF with genomic modification High High High-resolution, …

… The functional noncoding genome can be broadly divided into cis-regulatory DNA elements
… High-resolution interrogation of functional elements in the nongenome. Science 353, 1545–…

… By pairing high-resolution 3C interaction calls with nascent gene expression we interrogate
the … , as DpnII fragments are less likely to contain multiple functional elements than HindIII …

… noncoding regions introduce a multitude of challenges and research opportunities. In this
review, we introduce a spectrum of noncoding … complexity of the noncoding genome. We will …

A major challenge in genomics is to identify functional elements in the noncoding genome. …
) mutagenesis screens of noncoding regions have emerged as a novel method for finding …

… methods to interrogate the intrinsic structure of lncRNAs as well as their genomic localization
and … Understanding the functional elements of lncRNAs may allow lncRNA functions to be …

… Compared with the previously described approaches, this method, which does not involve
RNA denaturation and affinity tag design, not only preserves lncRNA functional elements but …

… noncoding genome affects gene regulation and disease, yet we lack tools for rapid identification
and manipulation of noncoding elements… We find that noncoding locations that modulate …

… within the non-coding part of the genome, potentially … functional annotation of NCREs is a
major driver of genome research. Compared with our knowledge of other regulatory elements, …