Epistasis, the interaction between genes, has become a major topic in molecular and
quantitative genetics. It is believed that these interactions play a significant role in genetic
variations causing complex diseases. Several algorithms have been employed to detect
pairwise interactions in genome-wide association studies (GWAS) but revealing higher
order interactions remains a computationally challenging task. State of the art tools are not
able to perform exhaustive search for all three-locus interactions in reasonable time even for …