The mechanosensitive channels of large conductance (MscL) are bacterial membrane
proteins that serve as last resort emergency release valves in case of severe osmotic
downshock. Sensing bilayer tension, MscL channels are sensitive to changes in the bilayer
environment and are, therefore, an ideal test case for exploring membrane protein coupling.
Here, we use high-throughput coarse-grained molecular dynamics simulations to
characterize MscL gating kinetics in different bilayer environments under the influence of …