Background Histamine is an immune modulator, neuroprotective, and remyelinating agent,
beneficially acting on skeletal muscles and promoting anti‐inflammatory features in
amyotrophic lateral sclerosis (ALS) microglia. Drugs potentiating the endogenous release of
histamine are in trial for neurological diseases, with a role not systematically investigated in
ALS. Here, we examine histamine pathway associations in ALS patients and the efficacy of a
histamine‐mediated therapeutic strategy in ALS mice. Methods We adopted an integrative …