Histone H3 phosphoacetylation is critical for heroin-induced place preference
J Sheng, Z gang Lv, L Wang, Y Zhou, B Hui - Neuroreport, 2011 - journals.lww.com
We investigated the role of histone H3 phosphoacetylation in the nucleus accumbens (NAc)
in heroin-conditioned place preference paradigm. Heroin could dose-dependently increase
histone H3 phosphoacetylation specifically in the NAc and could enhance heroin place
preference. Injection of trichostatin A into the NAc significantly augmented heroin-induced
histone H3 phosphoacetylation and enhanced heroin place preference. Conversely,
injection of MK-801 into the NAc attenuated histone H3 phosphoacetylation and reduced …
in heroin-conditioned place preference paradigm. Heroin could dose-dependently increase
histone H3 phosphoacetylation specifically in the NAc and could enhance heroin place
preference. Injection of trichostatin A into the NAc significantly augmented heroin-induced
histone H3 phosphoacetylation and enhanced heroin place preference. Conversely,
injection of MK-801 into the NAc attenuated histone H3 phosphoacetylation and reduced …
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