Von Meyenburg complex (VMC) is generally thought to be benign, although its
preneoplastic potential for intrahepatic cholangiocarcinoma (iCC) has been a subject of
contention. We retrospectively reviewed 86 hepatectomy specimens with a diagnosis of iCC.
Morphologically, an association between iCC and VMC was appreciated in 35% of cases
that illustrated a gradual neoplastic progression from benign VMC to dysplasia and then to
iCC. Among them, 24 cases had VMC lined by epithelial cells with low-grade biliary …