In this study we generally describe the hole-in-head disease and introduce a new method of treatment that called cupping. Cupping is important and old treatment for specific diseases in human, used by Iranian and Chinese medicinists in the past. This disease, often called hexamitiasis, is caused by a member of the genus Hexamita or Spironucleus. This parasite has two forms of infection one of them is external and cause hole-in-head disease and the other form is internal that cause intestinal problems. Hole-in-head disease cause death in flower horn fishes which are expensive and very popular members of Cichlidae family. Flower horn fish is a genetically improved hybrid between Amphilophus labiatus and Amphilophus trimaculatus. This simple method of cupping combined with stress factors removal was applied by us for the treatment of external hexamitiasis resulting in more than 50% cases of fish health recovery. The first signs of heath in treated specimens become visible after 4-6 days of treatment.