… The fibrillization of TMEM106B into identical fibrillar structures in a wide … diverse
neurodegenerative diseases. This suggests that the formation of amyloid fibrils composed of …

… fragment of TMEM106B is a common finding in distinct human neurodegenerative diseases,
… was used to solve the structures of TMEM106B fibrils at a resolution of 2.7 Afrom post…

… TMEM106B fibrils in diverse neurodegenerative diseases such as … , the burden of TMEM106B
fibrillization is much higher in … Recent studies identified homotypic intracellular TMEM106B …

… diverse set of neurodegenerative conditions. The recognition that TMEM106B can form amyloid
fibrils and is present across … of TMEM106B levels or by affecting TMEM106B fibrillization. …

… brain to neurodegeneration will provide … over the age of 65. The hippocampus was chosen
as it is highly susceptible to atrophy with ageing and in several neurodegenerative diseases. …

… brains of patients with various neurodegenerative diseases (NDs) … fibril prevalence in several
human brain samples across various … mechanisms behind TMEM106B fibrillization in NDs. …

… Significantly, the burden of TMEM106B fibrillization … different methods should be conducted
to verify the amyloid protein properties of TMEM106B in various Neurodegenerative diseases…

… INTRODUCTION Neurodegenerative diseases (NDs) are diverse and characterized by
the … Two types of glycosylation with different functions occur in TMEM106B. Noncomplex …

… (TMEM106B) was first linked to neurodegenerative diseases, … TMEM106B has also been
implicated in neurodegenerative … individuals with various neurodegenerative conditions, such …

… feature of neurodegenerative diseases which is strongly modified by TMEM106B haplotype,
… Regardless of whether it is levels or the different TMEM106B protein isoforms, our view on …