Rapid advance in oncology leads to increasing survival of oncologic patients. More and
more of them live long enough to reach either the natural age of menopause or, as a side
effect of their oncotherapy, experience the cessation of gonadal function, leading to
premature ovarian insufficiency, with disturbing vasomotor symtoms and long-term negative
cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors
search endocrinologic help in the form of hormone replacement therapy (HRT). The …

Objective: Thousands of women are treated each year for cancer; many of these are already
in menopause, while other younger patients will go into early menopause due to surgery, or
chemotherapy, or the need for radiotherapy to the pelvic region. In most cases the oncologist
and the gynaecologist would advise these women against the use of HRT. The purpose of
this paper is to review biological and clinical evidences in favour and against HRT use in the
different tumours and to propose an algorithm that can help choosing the treatment for the …