Host defense peptide RNase 7 is down-regulated in the skin of diabetic patients with or without chronic ulcers, and its expression is altered with metformin
A Rodríguez-Carlos, V Trujillo, I Gonzalez-Curiel… - Archives of Medical …, 2020 - Elsevier
Background Diabetic foot ulcers (DFUs) are one of the main complications in patients with
type 2 diabetes mellitus (DM2), previous studies have reported that DM2 patients have lower
production of host defense peptides (HDP). Aim of the Study To investigate the expression of
RNase 7, cathelicidin, HBD-2, and psoriasin in biopsies obtained from DM2 patients with or
without DFU. Methods Biopsies from DFU patients grade 3 according to Wagner's
classification, from diabetic patients without ulcer and from healthy donors were obtained …
type 2 diabetes mellitus (DM2), previous studies have reported that DM2 patients have lower
production of host defense peptides (HDP). Aim of the Study To investigate the expression of
RNase 7, cathelicidin, HBD-2, and psoriasin in biopsies obtained from DM2 patients with or
without DFU. Methods Biopsies from DFU patients grade 3 according to Wagner's
classification, from diabetic patients without ulcer and from healthy donors were obtained …
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