… Immune tolerance induced by regulatory mechanisms is an … In therapeutic settings,
however, tolerance may significantly limit … cellular cytotoxicity by overcoming NK cell tolerance. …

… cells to NK cells can suppress their antitumor functions by downregulating NKG2D and
increasing NK cell … NK cell fratricide and augment NK cell-mediated antitumor immunity [23]. …

… a role in tolerance induction when initial T cell depletion is used. However, the role of
homeostasis in tolerance induction remains unknown. In this study, we serially analyzed the T cell …

… of accommodation or tolerance. Accommodation, a … tolerance is concerned, specific Tcell
tolerance has recently been demonstrated by grafting thymectomized, T cell- and NK cell…

… induction of neonatal tolerance or mixed chimerism … NK cells, a subset of lymphocytes that
classically has not been implicated in the alloresponse to solid organs (9). To isolate NK cell …

… of T1D regarding NK cell disfunction is … tolerance that leads to T1D development is due
ultimately to dysfunctional peripheral tolerance mechanisms associated with natural killer cells…

… Because T cells and NK cells are critical in bone marrow … targeting of radioresistant NK cells
and/or T cells in the recipient … tolerance in vivo after partial conditioning with in vivo NK cell …

… (which imposes a defect in T cells and B cells, but largely spares NK cells), nor by the …
CD8 + T cells. Conversely, the depletion of cells expressing killer cell lectin like receptor K1 (…

… CD56 neg /CD16 pos NK cells with an aberrant repertoire of … for NK cell receptors and the
engagement of NK cell antibody-… NK cell tolerance toward autologous cells expressing ‘self’ …

… The increased surface levels of TIM-3 on NK cells in cancers induce NK cell impairments
(61), while TIM-3 blockade results in increased NK cell cytotoxicity both in vitro and ex vivo (59, …