Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
Mice with a functional human immune system have the potential to allow in vivo studies of
human infectious diseases and to enable vaccine testing. To this end, mice need to fully
support the development of human immune cells, allow infection with human pathogens,
and be capable of mounting effective human immune responses. A major limitation of
humanized mice is the poor development and function of human myeloid cells and the
absence of human immune responses at mucosal surfaces, such as the lung. To overcome …
human infectious diseases and to enable vaccine testing. To this end, mice need to fully
support the development of human immune cells, allow infection with human pathogens,
and be capable of mounting effective human immune responses. A major limitation of
humanized mice is the poor development and function of human myeloid cells and the
absence of human immune responses at mucosal surfaces, such as the lung. To overcome …
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung (161.5)
T Willinger, A Rongvaux, H Takizawa… - The Journal of …, 2011 - journals.aai.org
Mice with a functional human immune system have the potential to allow in vivo studies of
human infectious diseases and to enable vaccine testing. To this end, mice need to fully
support the development of human immune cells, allow infection with human pathogens,
and be capable of mounting effective human immune responses. A major limitation of
humanized mice is the poor development and function of human myeloid cells and the
absence of human immune responses at mucosal surfaces such as the lung. To overcome …
human infectious diseases and to enable vaccine testing. To this end, mice need to fully
support the development of human immune cells, allow infection with human pathogens,
and be capable of mounting effective human immune responses. A major limitation of
humanized mice is the poor development and function of human myeloid cells and the
absence of human immune responses at mucosal surfaces such as the lung. To overcome …
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