Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature
WJ Black, D Stagos, SA Marchitti… - Pharmacogenetics …, 2009 - journals.lww.com
Objective The human aldehyde dehydrogenase (ALDH) gene superfamily consists of 19
genes encoding enzymes critical for NAD (P)+-dependent oxidation of endogenous and
exogenous aldehydes, including drugs and environmental toxicants. Mutations in ALDH
genes are the molecular basis of several disease states (eg Sjögren-Larsson syndrome,
pyridoxine-dependent seizures, and type II hyperprolinemia) and may contribute to the
etiology of complex diseases such as cancer and Alzheimer's disease. The aim of this …
genes encoding enzymes critical for NAD (P)+-dependent oxidation of endogenous and
exogenous aldehydes, including drugs and environmental toxicants. Mutations in ALDH
genes are the molecular basis of several disease states (eg Sjögren-Larsson syndrome,
pyridoxine-dependent seizures, and type II hyperprolinemia) and may contribute to the
etiology of complex diseases such as cancer and Alzheimer's disease. The aim of this …
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