Human iPSC-derived cardiomyocytes are susceptible to SARS-CoV-2 infection

A Sharma, G Garcia, Y Wang, JT Plummer… - Cell Reports …, 2020 - cell.com
… of SARS-CoV-2 on hiPSC-CMs. We show that hiPSC-CMs are susceptible to SARS-CoV-2
infection, … impacts, establishing an in vitro cardiac platform to study SARS-CoV-2 infection. …

[HTML][HTML] Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis

W Wang, J Yang, P Kang, J Bai, X Feng, L Huang… - Virologica …, 2023 - ncbi.nlm.nih.gov
… protein was detected in both cardiomyocytes and endothelial cells in SARS-CoV-2-… The
cardiac endothelial cells might exhibit a distinct gene expression pattern thus be susceptible in …

SARS-CoV-2 infection of human iPSCderived cardiac cells reflects cytopathic features in hearts of patients with COVID-19

JA Perez-Bermejo, S Kang, SJ Rockwood… - Science translational …, 2021 - science.org
cardiomyocytes were readily infected with SARS-CoV-2, … that hiPSC-CMs are susceptible
to SARS-CoV-2 infection (31, 32), … the relative susceptibility to SARS-CoV-2 infection of three …

[HTML][HTML] SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

JA Pérez-Bermejo, S Kang, SJ Rockwood… - BioRxiv, 2020 - ncbi.nlm.nih.gov
… To validate these predictions, we exposed human iPSC-derived CMs, CFs, ECs, or a … of
iPSC-derived cardiomyocytes, primary fetal cardiac fibroblasts, and iPSC-derived endothelial …

Tumor necrosis factor-alpha exacerbates viral entry in SARS-CoV2-infected iPSC-derived cardiomyocytes

CY Lee, CH Huang, E Rastegari… - International journal of …, 2021 - mdpi.com
… Recent reports have shown that human iPSC-derived cardiomyocytes are susceptible to …
impact of the SARS-CoV-2 infection on human iPSC-derived functional cardiomyocytes (iCMs). …

SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes

J Liu, S Wu, Y Zhang, C Wang, S Liu, J Wan… - Stem Cell Research & …, 2023 - Springer
SARS-CoV-2 infection and Orf9c overexpression in hPSC-CMs suggests that other SARS-CoV-2
In this study, we highlight the susceptibility of hPSC-CMs to three SARS-CoV-2 genes: …

[HTML][HTML] SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

S Marchiano, TY Hsiang, A Khanna, T Higashi… - Stem cell reports, 2021 - cell.com
… directly by viral infection or are secondary to a systemic response. Here, we examine the
cardiac tropism of SARS-CoV-2 in human pluripotent stem cell-derived cardiomyocytes (hPSC-…

SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP Level

J Liu, Y Zhang, S Wu, L Han, C Wang, S Liu… - bioRxiv, 2022 - biorxiv.org
… DEGs caused by SARS-CoV-2 infection were significantly … that SARS-CoV-2 virus
could infect human ESC/iPSC-derived … the susceptibility of hPSC-CMs to individual SARS-CoV-2

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

TL Williams, MT Colzani, RGC Macrae… - Communications …, 2021 - nature.com
… are more susceptible to severe infection with SARS-CoV-2, … using human embryonic stem
cell-derived cardiomyocytes, … mRNA in a human iPSC-derived cardiomyocyte model 5 but the …

Highly efficient SARS-CoV-2 infection of human cardiomyocytes: spike protein-mediated cell fusion and its inhibition

CK Navaratnarajah, DR Pease, PJ Halfmann… - Journal of …, 2021 - Am Soc Microbiol
… of cardiac tissue by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
SARS-CoV-2 in spontaneously beating human induced pluripotent stem cell-derived cardiomyocytes