[HTML][HTML] Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5′-untranslated region
Febs Letters, 2011•Elsevier
Coinfection with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV)
accelerates hepatitis C disease progression; however, the mechanism underlying this effect
is unknown. Here, we investigated the role of HIV-1 in HCV gene expression and the
mechanism involved in this regulation. We discovered that HIV-1 Rev protein activates HCV
gene expression. We further revealed that Rev binds to the internal loop of the HCV 5′-
untranslated region (5′-UTR) to stimulate HCV IRES-mediated translation.
accelerates hepatitis C disease progression; however, the mechanism underlying this effect
is unknown. Here, we investigated the role of HIV-1 in HCV gene expression and the
mechanism involved in this regulation. We discovered that HIV-1 Rev protein activates HCV
gene expression. We further revealed that Rev binds to the internal loop of the HCV 5′-
untranslated region (5′-UTR) to stimulate HCV IRES-mediated translation.
Coinfection with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) accelerates hepatitis C disease progression; however, the mechanism underlying this effect is unknown. Here, we investigated the role of HIV-1 in HCV gene expression and the mechanism involved in this regulation. We discovered that HIV-1 Rev protein activates HCV gene expression. We further revealed that Rev binds to the internal loop of the HCV 5′-untranslated region (5′-UTR) to stimulate HCV IRES-mediated translation.
Elsevier
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