[HTML][HTML] Human pluripotent stem cell-derived organoids as models of liver disease
MNB Ramli, YS Lim, CT Koe, D Demircioglu, W Tng… - Gastroenterology, 2020 - Elsevier
Background & Aims There are few in vitro models for studying the 3-dimensional interactions
among different liver cell types during organogenesis or disease development. We aimed to
generate hepatic organoids that comprise different parenchymal liver cell types and have
structural features of the liver, using human pluripotent stem cells. Methods We cultured H1
human embryonic stem cells (WA-01, passage 27-40) and induced pluripotent stem cells
(GM23338) with a series of chemically defined and serum-free media to induce formation of …
among different liver cell types during organogenesis or disease development. We aimed to
generate hepatic organoids that comprise different parenchymal liver cell types and have
structural features of the liver, using human pluripotent stem cells. Methods We cultured H1
human embryonic stem cells (WA-01, passage 27-40) and induced pluripotent stem cells
(GM23338) with a series of chemically defined and serum-free media to induce formation of …
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