Bone metastases are devastating complications of cancer. They are particularly common in
prostate cancer (PCa), represent incurable disease, and are refractory to immunotherapy.
We seek to define distinct features of the bone marrow (BM) microenvironment by analyzing
single cells from bone metastatic prostate tumors, involved BM, uninvolved BM, and BM from
cancer-free, orthopedic patients, and healthy individuals. Metastatic PCa is associated with
multifaceted immune distortion, specifically exhaustion of distinct T cell subsets, appearance …

Bone metastases are devastating complications of cancer. They are particularly common in
prostate cancer, represent incurable disease and are refractory to immunotherapy. We
sought to define distinct features of the bone marrow microenvironment by analyzing single
cells from prostate cancer patients' involved bone, uninvolved bone and distant bone sites
as well as bone from cancer-free, orthopedic patients and healthy individuals. Metastatic
prostate cancer was associated with multifaceted immune distortion, specifically exhaustion …