Hyaluronic acid as a potential boron carrier for BNCT: Preliminary evaluation
A Zaboronok, T Yamamoto, K Nakai, F Yoshida… - Applied Radiation and …, 2015 - Elsevier
Hyaluronic acid (HA), a nonimmunogenic, biocompatible polymer found in different
biological tissues, has the potential to attach to CD44 receptors on the surface of certain
cancer cells, where the receptor is overexpressed compared with normal cells. Boron–
hyaluronic acid (BHA) was tested for its feasibility as a potential agent for BNCT. BHA with
low-viscosity 30 kDa HA could be administered by intravenous injection. The compound
showed a certain degree of cytotoxicity and accumulation in C6 rat glioma cells in vitro …
biological tissues, has the potential to attach to CD44 receptors on the surface of certain
cancer cells, where the receptor is overexpressed compared with normal cells. Boron–
hyaluronic acid (BHA) was tested for its feasibility as a potential agent for BNCT. BHA with
low-viscosity 30 kDa HA could be administered by intravenous injection. The compound
showed a certain degree of cytotoxicity and accumulation in C6 rat glioma cells in vitro …
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