Multicellular spheroids made of stem cells can act as building blocks that fuse to capture
complex aspects of native in vivo environments, but the effect of hydrogel viscoelasticity on
cell migration from spheroids and their fusion remains largely unknown. Here, we
investigated the effect of viscoelasticity on migration and fusion behavior of mesenchymal
stem cell (MSC) spheroids using hydrogels with a similar elasticity but different stress
relaxation profiles. Fast relaxing (FR) matrices were found to be significantly more …