• Several clinical and physiologic associations between depression and diabetes mellitus
have been reported. In this study, a potential neuroendocrine association was studied by
measuring hypothalamic-pituitary-adrenocortical (HPA) axis activity in patients with diabetes
mellitus. Plasma cortisol levels and response to dexamethasone administration were
determined in 54 diabetics. Twenty-three (55%) of forty-two 1-mg dexamethasone
suppression tests (DSTs) performed in 34 subjects, with eight repeated tests, and two (10%) …