Hypoxia-targeted radiotherapy dose painting for head and neck cancer using ¹⁸F-FMISO PET: A biological modeling study
BACKGROUND: This study investigates the use of (18) F-fluoromisonidazole (FMISO) PET-
guided radiotherapy dose painting for potentially overcoming the radioresistant effects of
hypoxia in head and neck squamous cell carcinoma (HNSCC). MATERIAL AND METHODS:
The study cohort consisted of eight patients with HNSCC who were planned for definitive
radiotherapy. Hypoxic subvolumes were automatically generated on pre-radiotherapy
FMISO PET scans. Three radiotherapy plans were generated for each patient: a standard …
guided radiotherapy dose painting for potentially overcoming the radioresistant effects of
hypoxia in head and neck squamous cell carcinoma (HNSCC). MATERIAL AND METHODS:
The study cohort consisted of eight patients with HNSCC who were planned for definitive
radiotherapy. Hypoxic subvolumes were automatically generated on pre-radiotherapy
FMISO PET scans. Three radiotherapy plans were generated for each patient: a standard …
Hypoxia-targeted radiotherapy dose painting for head and neck cancer using 18F-FMISO PET: A biological modeling study
Background. This study investigates the use of 18F-fluoromisonidazole (FMISO) PET-guided
radiotherapy dose painting for potentially overcoming the radioresistant effects of hypoxia in
head and neck squamous cell carcinoma (HNSCC). Material and methods. The study cohort
consisted of eight patients with HNSCC who were planned for definitive radiotherapy.
Hypoxic subvolumes were automatically generated on pre-radiotherapy FMISO PET scans.
Three radiotherapy plans were generated for each patient: a standard (STD) radiotherapy …
radiotherapy dose painting for potentially overcoming the radioresistant effects of hypoxia in
head and neck squamous cell carcinoma (HNSCC). Material and methods. The study cohort
consisted of eight patients with HNSCC who were planned for definitive radiotherapy.
Hypoxic subvolumes were automatically generated on pre-radiotherapy FMISO PET scans.
Three radiotherapy plans were generated for each patient: a standard (STD) radiotherapy …
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