Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage
M Sugimoto, A Gromley, CJ Sherr - Molecular and cellular biology, 2006 - Am Soc Microbiol
The hematopoietic zinc finger protein, Hzf, is induced in response to genotoxic and
oncogenic stress. The Hzf protein is encoded by a p53-responsive gene, and its
overexpression, either in cells retaining or lacking functional 53, halts their proliferation.
Enforced expression of Hzf led to the appearance of tetraploid cells with supernumerary
centrosomes and, ultimately, to cell death. Eliminating Hzf mRNA expression by use of short
hairpin (sh) RNAs had no overt effect on unstressed cells but inhibited the maintenance of G …
oncogenic stress. The Hzf protein is encoded by a p53-responsive gene, and its
overexpression, either in cells retaining or lacking functional 53, halts their proliferation.
Enforced expression of Hzf led to the appearance of tetraploid cells with supernumerary
centrosomes and, ultimately, to cell death. Eliminating Hzf mRNA expression by use of short
hairpin (sh) RNAs had no overt effect on unstressed cells but inhibited the maintenance of G …
[引用][C] Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage.
杉本昌隆 - Molecular and Cellular Biology 26・2, 2006 - cir.nii.ac.jp
Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by
DNA damage. | CiNii Research … Hzf, a p53-responsive gene, regulates maintenance of
the G2 phase checkpoint induced by DNA damage. … タイトル Hzf, a p53-responsive gene,
regulates maintenance of the G2 phase checkpoint induced by DNA damage. …
DNA damage. | CiNii Research … Hzf, a p53-responsive gene, regulates maintenance of
the G2 phase checkpoint induced by DNA damage. … タイトル Hzf, a p53-responsive gene,
regulates maintenance of the G2 phase checkpoint induced by DNA damage. …
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