Identification of a synergistic multi-drug combination active in cancer cells via the prevention of spindle pole clustering

A Weiss, M Le Roux-Bourdieu, M Zoetemelk… - Cancers, 2019 - mdpi.com
… for rapid in vitro identification of optimized, synergistic low-dose multi-drug combinations [8,9…
phenotypically-driven method identifies synergistic drug mixtures with minimal experimental …

Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination

W Zhao, XD Zheng, PYZ Tang, HM Li… - Medicinal Research …, 2023 - Wiley Online Library
… in cells may have a more significant or synergistic anticancer … identification of a variety
of terpenoids that inhibit cancer cell … of Compound 30 against multi-drug resistant cells (A549/…

Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death

W Tian, Y Deng, L Li, H He… - … Journal of Oncology, 2013 - spandidos-publications.com
… types of programmed cell death by multi-drug treatment regimen is a … Mechanisms of the
synergistic activation are mainly … was identified by DNA gel electrophoresis in MCF-7/ADR cells

[HTML][HTML] Multiple strategies with the synergistic approach for addressing colorectal cancer

C Karthika, B Hari, MH Rahman, R Akter… - Biomedicine & …, 2021 - Elsevier
Cancer treatment is improving widely over time, but finding a proper defender to beat them
seems like a distant dream. The quest for identification and … of the cancer cells using multiple …

Drug repurposing to identify a synergistic high-order drug combination to treat sunitinib-resistant renal cell carcinoma

M Rausch, A Rutz, PM Allard, C Delucinge-Vivier… - Cancers, 2021 - mdpi.com
… of the ODC, maintaining an efficacy of over 70%. Our results show that repurposed drugs
can be combined to target cancer cells selectively with prominent activity. The strong impact on …

Potential synergism of natural products in the treatment of cancer

S HemaIswarya, M Doble - Phytotherapy Research: An …, 2006 - Wiley Online Library
… The identification of synergistic combinations and their … inhibit the growth of tumor cells,
when combined with genistein it … by curcumin in multi-drug resistant human KB cells. Biochem …

Anticancer therapeutics:“Addictive” targets, multi-targeted drugs, new drug combinations

HJ Broxterman, NH Georgopapadakou - Drug Resistance Updates, 2005 - Elsevier
… the cancer cell and identifyingcombination of an anti-VEGF monoclonal antibody (bevacizumab)
or VEGFR2 blocker with cytotoxic therapy is hypothesized to be potentially synergistic

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

RS Narayan, P Molenaar, J Teng… - Nature …, 2020 - nature.com
… to identify commonly occurring co-vulnerabilities in cancer cell … Since we identified synergistic
drug pairs for cell lines that … might be predictive for the effectiveness of multi-drug synergy

Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro

J Shan, Y Xuan, S Ruan, M Sun - Chinese journal of integrative medicine, 2011 - Springer
… Drug-resistance in tumor cells is one of the principal causes for chemotherapy failure in …
drugresistant protein mediated multi-drug resistance (MDR) and the over-expressed anti-…

SynergyFinder 2.0: visual analytics of multi-drug combination synergies

A Ianevski, AK Giri, T Aittokallio - Nucleic acids research, 2020 - academic.oup.com
… approach to identify new synergistic drug combinations, ie combinations that result in a …
Identification of a synergistic Multi-Drug combination active in cancer cells via the prevention