Identification of candidate COVID-19 therapeutics using hPSC-derived lung organoids

Y Han, L Yang, X Duan, F Duan, BE Nilsson-Payant… - BioRxiv, 2020 - biorxiv.org
… amongst human COVID-19 pulmonary infections. We performed a high throughput screen
using hPSC-derived lung organoids and identified FDA-approved drug candidates, including …

Attenuating Cytokine Storm Initiation Caused by Influenza and SARS-CoV-2 Using hPSC-Derived Lung Organoids

MG Rea-Moreno - 2024 - search.proquest.com
… within the body, identifying the precise mechanism triggering … and explore potential
therapeutic approaches to mitigate the … As we mark the fifth year since the onset of the COVID-19

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Y Han, X Duan, L Yang, BE Nilsson-Payant, P Wang… - Nature, 2021 - nature.com
… resource for drug screening to identify candidate COVID-19 therapeutics. … hPSC-derived
LO and CO models that can be applied to screen for drug candidates for patients with COVID-19

Induced pluripotent stem cell-based disease modeling and prospective immune therapy for coronavirus disease 2019

K Chakrabarty, R Shetty, S Argulwar, D Das, A Ghosh - Cytotherapy, 2022 - Elsevier
… for coronavirus disease 2019 (COVID-19) therapeutics [11,12]. … [45] utilized hPSC-derived
lung organoids to investigate the … this a tempting immune cell candidate for COVID-19 therapy. …

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

M Kiener, N Roldan, C Machahua, A Sengupta… - Frontiers in …, 2021 - frontiersin.org
… of fibrotic lung organoids in order to identify aberrantly … Co-culture models of hPSC-derived
lung organoids and hPSC-derived … We expect that personalized therapy will also improve the …

Human embryonic stem cell-derived lung organoids: a model for SARS-CoV-2 infection and drug test

R Pei, J Feng, Y Zhang, H Sun, L Li, X Yang, J He… - BioRxiv, 2020 - biorxiv.org
… The coronavirus disease 2019 (COVID-19) pandemic is … of a variety of potential therapeutic
drugs 7 . However, these … viral RNA detection and infectious viral particle titration results. …

[HTML][HTML] Human pluripotent stem cells for the modelling and treatment of respiratory diseases

PA Goldsteen, C Yoseif, AM Dolga… - European Respiratory …, 2021 - Eur Respiratory Soc
… The current COVID-19 pandemic is a perfect opportunity for … to show how these hPSC-derived
models can aid our … , hPSC-derived human somatic cells could be used as therapy

[PDF][PDF] iPSC-based disease modeling and prospective immune therapy for COVID-19

K Chakrabarty, R Shetty, S Argulwar, D Das… - …, 2021 - researchgate.net
… T cell therapies can be a powerful tool to treat COVID-19 … in COVID 19, it is empirical to
rationalize its use in COVID-19 … iPSCs derived airway epithelial cells and 3D-lung organoids

Advancing lung organoids for COVID-19 research

J van der Vaart, MM Lamers… - Disease Models & …, 2021 - journals.biologists.com
… Against this backdrop, we highlight that the COVID-19 pandemic has fuelled the development
of … Identification of candidate COVID-19 therapeutics using hPSC-derived lung organoids

Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy

R Dagher, A Moldobaeva, E Gubbins, S Clark… - Stem Cells, 2024 - academic.oup.com
… confirmed the potency of this therapy to prevent SARS-CoV-2 … conserved in our infected
organoid cocultures. These DEG … of mAbs as candidates for use as COVID-19 preventative …