Identification of direct thyroid hormone response genes reveals the earliest gene regulation programs during frog metamorphosis
Thyroid hormone (T3) is essential for normal development and organ function throughout
vertebrates. Its effects are mainly mediated through transcriptional regulation by T3 receptor
(TR). The identification and characterization of the immediate early, direct target genes are
thus of critical importance in understanding the molecular pathways induced by T3.
Unfortunately, this has been hampered by the difficulty to study gene regulation by T3 in
uterus-enclosed mammalian embryos. Here we used Xenopus metamorphosis as a model …
vertebrates. Its effects are mainly mediated through transcriptional regulation by T3 receptor
(TR). The identification and characterization of the immediate early, direct target genes are
thus of critical importance in understanding the molecular pathways induced by T3.
Unfortunately, this has been hampered by the difficulty to study gene regulation by T3 in
uterus-enclosed mammalian embryos. Here we used Xenopus metamorphosis as a model …
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