Astrocytes are the most abundant cell type in the brain, where they perform a wide array of
functions, yet the nature of their cellular heterogeneity and how it oversees these diverse
roles remains shrouded in mystery. Using an intersectional fluorescence-activated cell
sorting–based strategy, we identified five distinct astrocyte subpopulations present across
three brain regions that show extensive molecular diversity. Application of this molecular
insight toward function revealed that these populations differentially support synaptogenesis …